We work on the functional evolution of toxin-antitoxins and proteins that interact with the ribosome, and that are involved in antibiotic resistance and response to stress. Our methods are bioinformatics, microbiology and biochemistry.
Sequence analyses of small alarmone synthetases, developer of our FlaGs (Flanking Genes) tool
Validation and characterisation of novel toxin-antitoxin systems
Structural analyses of Toxin-Antitoxin systems (co-supervised with Karina Persson and Gerhard Gröbner)
Evolution of protein sequence, structure and function
Alumni:
Victoriia Murina:
Biochemistry of antibiotic resistance conferred by Staphylococcus Aureus Vga(A) and other ABCF ATPases
Tonu Margus, post-doc:
Bioinformatic analyses of yeast ribosome profiling data to understand the role of enigmatic translation factors
Marje Kasari, post-doc:
Marje worked with us on biochemistry and microbiology of Entercoccus faecalis Lsa and other antibiotic resistance ABCF ATPases
We collaborate extensively with the lab of Vasili Hauryliuk
