Big thanks to the Knut and Alice Wallenberg Foundation for funding our research on toxin-antitoxin systems for 5 years! https://kaw.wallenberg.org/en/press/total-sek-541-million-granted-18-research-projects-sweden?fbclid=IwAR2bqEsQutcVyqpVmGsUDKZaZ8HLhCtg7wF9AEocCkggtU9SVfVJeTazsio
Happy to report that the paper reporting our tools FlaGs and WebFlaGs will soon be published. Give them a try here: http://webflags.se/
This was a really fun collaboration with the Wilson and Hauryliuk labs. Ribosomal protein synthesis without the small subunit, classical translation factors or even mRNA! Fun things happen during ribosome quality control
Target protection as a key antibiotic resistance mechanism https://www.nature.com/articles/s41579-020-0386-z
hope to share final version soon!
INTEGRATED STRUCTURAL BIOLOGY (ISB) POSTDOCTORAL PROGRAM PROJECT SUMMARY: Bacterial toxin-antitoxin (TA) systems have diverse functions, including defence against phages and maintenance of genetic elements. The lab of Gemma C. Atkinson has discovered a large network of promiscuous toxin-antitoxin domain pairs that swap partners across vast evolutionary distances. These novel TAs are being characterised microbiologically and…
Check it out on BioRxiv! A role for the Saccharomyces cerevisiae ABCF protein New1 during translation termination https://doi.org/10.1101/638064 This was another fun collaboration with the Hauryliuk and Wilson labs
Read all about our exciting discovery of a new toxin-antitoxin system here! https://www.biorxiv.org/content/10.1101/575399v2
Our ABCF paper available on BioRxiv here has been accepted to the Journal of Molecular Biology. It will appear in a special issue on antibiotic resistance in early 2019.