Target protection as a key antibiotic resistance mechanism https://www.nature.com/articles/s41579-020-0386-z
hope to share final version soon!
INTEGRATED STRUCTURAL BIOLOGY (ISB) POSTDOCTORAL PROGRAM PROJECT SUMMARY: Bacterial toxin-antitoxin (TA) systems have diverse functions, including defence against phages and maintenance of genetic elements. The lab of Gemma C. Atkinson has discovered a large network of promiscuous toxin-antitoxin domain pairs that swap partners across vast evolutionary distances. These novel TAs are being characterised microbiologically and…
Check it out on BioRxiv! A role for the Saccharomyces cerevisiae ABCF protein New1 during translation termination https://doi.org/10.1101/638064 This was another fun collaboration with the Hauryliuk and Wilson labs
Read all about our exciting discovery of a new toxin-antitoxin system here! https://www.biorxiv.org/content/10.1101/575399v2
Our ABCF paper available on BioRxiv here has been accepted to the Journal of Molecular Biology. It will appear in a special issue on antibiotic resistance in early 2019.
In this joint Hauryliuk/Johansson/Atkinson lab venture we aimed to establish the primary function of yeast eEF3: Elongation factor? Ribosome recycling factor? https://www.biorxiv.org/content/early/2018/09/10/413252
A great collaboration with the Wilson lab on the structure of ARE ABCF VmlR on the ribosome! http://www.pnas.org/content/early/2018/08/15/1808535115
FlaGs is a Python application for analysing conservation of gene neighbourhoods, and creating publication-quality figures. I’m very proud of my PhD student Chayan Kumar Saha for his heroic effort making this tool! Well done Chayan! The paper is here: https://www.biorxiv.org/content/early/2018/07/04/362095 And the tool itself is here: https://github.com/GCA-VH-lab/FlaGs Some example output: