Big thanks to the Knut and Alice Wallenberg Foundation for funding our research on toxin-antitoxin systems for 5 years! https://kaw.wallenberg.org/en/press/total-sek-541-million-granted-18-research-projects-sweden?fbclid=IwAR2bqEsQutcVyqpVmGsUDKZaZ8HLhCtg7wF9AEocCkggtU9SVfVJeTazsio
INTEGRATED STRUCTURAL BIOLOGY (ISB) POSTDOCTORAL PROGRAM PROJECT SUMMARY: Bacterial toxin-antitoxin (TA) systems have diverse functions, including defence against phages and maintenance of genetic elements. The lab of Gemma C. Atkinson has discovered a large network of promiscuous toxin-antitoxin domain pairs that swap partners across vast evolutionary distances. These novel TAs are being characterised microbiologically and…
Check it out on BioRxiv! A role for the Saccharomyces cerevisiae ABCF protein New1 during translation termination https://doi.org/10.1101/638064 This was another fun collaboration with the Hauryliuk and Wilson labs
Read all about our exciting discovery of a new toxin-antitoxin system here! https://www.biorxiv.org/content/10.1101/575399v2
Our ABCF paper available on BioRxiv here has been accepted to the Journal of Molecular Biology. It will appear in a special issue on antibiotic resistance in early 2019.
In this joint Hauryliuk/Johansson/Atkinson lab venture we aimed to establish the primary function of yeast eEF3: Elongation factor? Ribosome recycling factor? https://www.biorxiv.org/content/early/2018/09/10/413252
A great collaboration with the Wilson lab on the structure of ARE ABCF VmlR on the ribosome! http://www.pnas.org/content/early/2018/08/15/1808535115
FlaGs is a Python application for analysing conservation of gene neighbourhoods, and creating publication-quality figures. I’m very proud of my PhD student Chayan Kumar Saha for his heroic effort making this tool! Well done Chayan! The paper is here: https://www.biorxiv.org/content/early/2018/07/04/362095 And the tool itself is here: https://github.com/GCA-VH-lab/FlaGs Some example output:
Very excited to say that our paper “Antibiotic resistance ABCF proteins reset the peptidyl transferase centre of the ribosome to counter translational arrest” is now published in Nucleic Acids Research! Here’s the link! A big well done and thank you to post-docs Marje Kasari and Victoriia Murina for all their hard work!
Link coming soon! Happy Christmas!