INTEGRATED STRUCTURAL BIOLOGY (ISB) POSTDOCTORAL PROGRAM PROJECT SUMMARY: Bacterial toxin-antitoxin (TA) systems have diverse functions, including defence against phages and maintenance of genetic elements. The lab of Gemma C. Atkinson has discovered a large network of promiscuous toxin-antitoxin domain pairs that swap partners across vast evolutionary distances. These novel TAs are being characterised microbiologically and…
In this joint Hauryliuk/Johansson/Atkinson lab venture we aimed to establish the primary function of yeast eEF3: Elongation factor? Ribosome recycling factor? https://www.biorxiv.org/content/early/2018/09/10/413252
A great collaboration with the Wilson lab on the structure of ARE ABCF VmlR on the ribosome! http://www.pnas.org/content/early/2018/08/15/1808535115
FlaGs is a Python application for analysing conservation of gene neighbourhoods, and creating publication-quality figures. I’m very proud of my PhD student Chayan Kumar Saha for his heroic effort making this tool! Well done Chayan! The paper is here: https://www.biorxiv.org/content/early/2018/07/04/362095 And the tool itself is here: https://github.com/GCA-VH-lab/FlaGs Some example output:
Very excited to say that our paper “Antibiotic resistance ABCF proteins reset the peptidyl transferase centre of the ribosome to counter translational arrest” is now published in Nucleic Acids Research! Here’s the link! A big well done and thank you to post-docs Marje Kasari and Victoriia Murina for all their hard work!
Link coming soon! Happy Christmas!
ABCF ATPases involved in protein synthesis, ribosome assembly and antibiotic resistance: structural and functional diversification across the tree of life Click here!
Our PNAS paper on the small alarmone synthetase RelQ is out! Negative allosteric regulation of Enterococcus faecalis small alarmone synthetase RelQ by single-stranded RNA. Beljantseva J, Kudrin P, Andresen L, Shingler V, Atkinson GC, Tenson T, Hauryliuk V. Proc Natl Acad Sci U S A. 2017 Mar 20. pii: 201617868. doi: 10.1073/pnas.1617868114.